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KMID : 0525720180230030158
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Journal of Chitin and Chitosan
2018 Volume.23 No. 3 p.158 ~ p.163
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Quantum Dot and Iron Oxide Nanoparticle-Loaded Chitosan Nanoparticles for Cancer Imaging
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Kim Min-Ah
Jeong Hwan-Jeong
Lee Chang-Moon
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Abstract
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In this study, we report superparamagnetic iron oxide nanoparticles (SPION) and quantum dots (Q-Dots)-loaded glycol chitosan (GC) nanoparticles as a dual imaging probe for tumor imaging. From GC modified with histidine self-assembled GC nanoparticles containing SPION and Q-Dots were prepared as a dual imaging probe. Tumor accumulation of the GC nanoparticles was investigated through optical and magnetic resonance imaging in a MDA-MB231 breast mouse cancer model. The SPION and Q-Dots-loaded GC nanoparticles were successfully accumulated into tumor by prolonged circulation and enhanced permeability and retention effect. As expected, in ex vivo study, the SPION and Q-Dots-loaded GC nanoparticles showed higher uptake in tumor than the other organs. The SPION and Q-Dots-loaded GC nanoparticles are a promising imaging agent for cancer imaging and can be used as a cancer-targeted drug delivery for chemotherapy.
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KEYWORD
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Glycol chitosan, Q-Dots, Iron oxide nanoparticles, Tumor imaging, Multiprobe
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